Journal: Journal of Hepatology
Article Title: Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
doi: 10.1016/j.jhep.2015.05.013
Figure Lengend Snippet: Comparable repression of metabolism-associated genes during cultivation of primary hepatocytes and differentiated HLC. (A) Correlation between genes repressed in primary hepatocytes after 14 days of cultivation in 2D (monolayer) conditions and genes deregulated in HLC (UKK-islands) compared to FH. The red dots represent the top 10%, while the purple and green dots correspond to the additional 20 and 40% genes with highest correlation. (B) Venn diagram analysis indicates the high overlap between top 10, 20, and 40% correlated genes with genes in cluster group II . The light blue circles represent genes in each cluster group as described in . Red circles represent genes in the top 10 to 40% with highest correlation, as described in A.
Article Snippet: For the present study, HLC were available from three different centers: University Klinik Köln, Germany (UKK), Medical Research Council Centre for Regenerative Medicine, Edinburgh UK (MRC) and Cellartis, Gothenburg, Sweden (CEL).
Techniques: